Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Nov 22;107(50):21795–21800. doi: 10.1073/pnas.1016485107

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 4. — Decreased Sufu expression significantly increases the number of oligodendrocyte precursors in vivo. (A) Western blot analysis of equal amounts of protein derived from brain lysates of wild-type (Sufu^+/+) mice or mice lacking one copy of Sufu (Sufu^+/−). (B) Olig2 staining in brain sections of Sufu^+/+ or Sufu^+/− E15.5 brains show an overall increase in Olig2-positive cells in Sufu^+/− brains. Higher magnifications in Lower. (Scale bar: 100 μm.) (C) The number of PDGFRα-positive cells in the forebrain is significantly increased in mice with decreased Sufu expression (Sufu^+/−) at E15.5 (Error bars are ±SD, ***P < 0.005, n = 3). (D) The increased number of PDGFRα-positive cells persists in the Sufu^+/− P2 forebrain. Error bars are ± SD, **P < 0.05, n = 3.