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. 2010 Nov 29;107(50):21553–21557. doi: 10.1073/pnas.1011081107

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Fig. 4. — FAN1/FANCC and FAN1/FANCJ double knockout DT40 cells are more sensitive to cisplatin than single mutants and display more chromosomal aberrations. (A) FAN1^−/−/FANCC^/− cells are more sensitive to cisplatin than wild-type, FAN1^−/−, or FANCC^/− single knockout cells. Each data point represents an average of at least three independent experiments ±SD. (B) FAN1^−/−/FANCC^/− cells display more and different distribution of chromosomal aberrations compared with wild-type, FAN1^−/−, or FANCC^/− single knockout cells. (C) FAN1^−/−/FANCJ^−/− cells are more sensitive to cisplatin than wild-type, FAN1^−/−, or FANCJ^−/− single knockout cells. Each data point represents an average of at least three independent experiments ±SD. (D) Occurrence of chromosomal aberrations in FAN1^−/−/FANCCJ^−/− cells compared with wild-type, FAN1^−/−, or FANCJ^−/− single knockout cells. (E) Sister chromatid exchange frequencies in wild type, FAN1^−/−, FANCC^/−, FANCJ^−/−, FAN1^−/−/FANCC^/−, or FAN1/FANCJ^−/− DT40 cells. The y axis shows the number of metaphases containing the number of SCEs indicated on the x axis. At least 50 metaphase spreads were counted for each experiment and the graph shows the mean number of SCEs.