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. 2010 Nov 29;107(50):21884–21889. doi: 10.1073/pnas.1008859107

Fig. 3.

Fig. 3.

Exogenous 9cRA induces glucose intolerance. (A) Increases in total pancreas 9cRA after dosing with 9-cis retinol or 9cRA (0.5 mg/kg in 100 μL DMSO). 9-cis retinol and 9cRA were injected 60 and 15 min before glucose, respectively. Glucose (2 g/kg) was injected at 0 min: five to eight mice per group; *P ≅ 0.01 and **P < 0.003 vs. vehicle control; &P < 0.005 vs. 0 min. (B) GTT in mice dosed with 9-cis retinol or 9cRA: five to seven mice per group; *P < 0.04, **P < 0.002, ***P < 0.005 vs. control. Mice were dosed with retinoids as described in A. All data are ±SEM.