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. 2010 Nov 16;107(50):21248–21255. doi: 10.1073/pnas.1015855107

Fig. 3.

Fig. 3.

Neutralization of G-CSF or Bv8 inhibits metastasis. (A) Number of metastases in lungs of mice bearing 4T1 tumors and treated with indicated antibodies (n = 10) for 5.5 wk after tumor inoculation. (B) Number of metastases per lung in mice bearing 66c14 tumors 6 wk after tumor inoculation. Tumors were implanted, and treatment was performed as in A (n = 10). (C) Representative images of lung sections from mice bearing 4T1 or 66c14 tumors and treated with the indicated antibodies. Sections correspond to A (4T1 tumors) or B (66c14 tumors). Arrowheads indicate metastases. (D) Average numbers of CK-18–positive tumor colonies per lung section of SCID/bg mice bearing MDA-MB-231-X1.1 tumors and treated with indicated antibodies for 7 wk. (E) Number of lung metastases in mice transplanted with either Bv8 WT (white bars) or Bv8 KO (gray bars) fetal liver cells and treated with indicated antibodies. (F) Numbers of lung metastases in mice bearing 66c14 tumors and treated with indicated antibody. Asterisk indicates significant difference relative to ISO group. Data shown are means ± SEM.