Fig. 2.

No differences in inflammation between WT and Casp1^−/− mice during acute DSS colitis. There were no significant difference in percent-mass change (A), colonoscopy inflammation severity score (B), severity of histopathological morphology (C) (H&E staining), or histopathology parameters for edema, inflammation, ulceration or overall severity of injury (D) between WT and Casp1^−/− mice. (Scale bars in C, 200 μm.) (E) Likewise, the severity of chronic DSS colitis was similar between WT and Casp1^−/− mice. All experiments were repeated twice.