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Potential cation-π interaction links SDL and SyMBS in integrin β7 subunit I domain. (A) Sequence alignment of the human integrin β subunit I domains. Residues at the position of F185 in β7 are shown in red. (B) Detailed view of the metal ion cluster, Y164 (F185 in β7) and SDL in integrin β3 I domain (pdb 2vdl). SyMBS, MIDAS, and ADMIDAS metal ions are magenta, gold, and green spheres, respectively. (C and D) Distances between SyMBS cation and Y164 aromatic ring.
