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. 2010 Nov 24;107(50):21818–21823. doi: 10.1073/pnas.1010669107

Fig. 4.

Fig. 4.

Ablation of ErbB4 in PV-positive neurons prevents NRG1 from increasing GABAergic transmission and suppressing LTP. (A) Representative eIPSC traces from control and PV-Cre;ErbB4−/− mice. (Right) Quantitative analysis of data with eIPSCs before application of 100% NRG1 (n = 9 for control; n = 8 for PV-Cre;ErbB4−/− mice). (B) Normalized fEPSP slopes from control and NRG1-treated hippocampal slices of indicated mice. (Right) Quantitative data (n = 4–6 slices). (C) NRG1 regulation of eIPSCs in CaMKII-Cre;ErbB4−/− mice. eIPSCs were recorded from CaMKII-Cre;ErbB4−/− mice (n = 9) or control littermates (n = 5). (D) NRG1 suppression of LTP induction in CaMKII-Cre;ErbB4−/− mice. Shown was % potentiation of fEPSP slopes that were recorded as Fig. 1 (n = 4–5 slices). *P < 0.05; **P < 0.01.