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. 2010 Dec;12(12):980–992. doi: 10.1593/neo.101146

Figure 1.

Figure 1

Dex induces myeloma cell cytotoxicity that is enhanced by radiation. Cell lines were treated with Dex and/or radiation, and cell death was determined by PI uptake (A, B) or clonogenic assay (C). (A) Myeloma cell cytotoxicity by Dex (1 εM) alone at 24 and 48 hours. *P < .05, ςP < .001 versus 24 hours. (B) Myeloma cell cytotoxicity with treatment of Dex (5 εM) alone, radiation (6 Gy) alone, or Dex plus radiation at 24 hours. *P < .05 versus Dex or IR, ςP < .001 versus IR, #P < .05 versus Dex. For panels A and B, results are mean of triplicate wells ± SD and representative of two independent experiments. The data are presented as percentage cell death relative to that in untreated controls. (C) NSF for myeloma (ANBL-6 or 5TGM1) and BMSCs (HS-5 or SR-4987) after Dex (5 εM) and/or 6 Gy of radiation. The results are representative of two independent experiments. *P < .0005 versus Dex or IR, ςP < .01 versus control. ns indicates not significant. For panels A, B, and C, all statistical comparisons are with the respective cell types.