Table 3.

Sensitization of Stably P-gp-expressing MDR1-Transduced Cells (UKF-NB-3^MDR1) to Vincristine by Saq, Saq-NO, or Verapamil.

	IC50* Vincristine (ng/ml)	Fold Sensitization†
Vincristine	13.17 ± 1.35
Vincristine + verapamil 10 µM	0.07 ± 0.004‡	188.1
Vincristine + saq 10 µM	3.21 ± 0.71‡	4.10
Vincristine + saq 5 µM	6.66 ± 1.72‡	2.0
Vincristine + saq 2.5 µM	9.41 ± 2.22	1.4
Vincristine + saq-NO 10 µM	0.11 ± 0.01‡,§	119.7
Vincristine + saq-NO 5 µM	0.85 ± 0.15‡,§	15.5
Vincristine + saq-NO 2.5 µM	3.35 ± 0.93‡,§	3.9

Values are mean ± SD from three independent experiments.

^*Concentration that decreases cell viability by 50%.

^†IC₅₀ vincristine/IC₅₀ vincristine + saq, saq-NO, or verapamil.

^‡P < .05 relative to vincristine alone.

^§P < .05 relative to vincristine + corresponding saq concentration.