Table 5.
IC50* Mitoxantrone (ng/ml) | Fold Sensitization† | |
Mitoxantrone | 45.87 ± 7.97 | |
Mitoxantrone + WK-X-34 1 µM | 0.17 ± 0.04‡ | 269.8 |
Mitoxantrone + saq 10 µM | 12.54 ± 1.88‡ | 3.7 |
Mitoxantrone + saq 5 µM | 34.77 ± 10.04 | 1.3 |
Mitoxantrone + saq 2.5 µM | 39.66 ± 10.44 | 1.2 |
Mitoxantrone + saq-NO 10 µM | 9.62 ± 3.24‡ | 4.8 |
Mitoxantrone + saq-NO 5 µM | 19.73 ± 3.64‡ | 2.3 |
Mitoxantrone + saq-NO 2.5 µM | 37.73 ± 14.21 | 1.2 |
Values are mean ± SD from three independent experiments.
Concentration that decreases cell viability by 50%.
IC50 mitoxantrone/IC50 mitoxantrone + saq, saq-NO, or WK-X-34.
P < .05 relative to mitoxantrone alone.