TABLE 1.
PHARMACOKINETIC PARAMETERS
| PK parameters Calculated | IV 4-chlorocurcumin (2.8 mg) | IP microsphere (20 mg) |
|---|---|---|
| T1/2 (h) | 1.987 | 82 |
| Vd (ml) | 23.52 | 50 |
| CL (ml/h) | 8.20 | 4.21 |
| AUC (μg.h/ml) | 227 | 300 |
| Tmax (h) | 0.5 | 1.0 |
| Cmax (μg/ml) | 196.43 | 39.82 |
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