TABLE 2.
EFFECT OF AAO ON PENTYLENETETRAZOL INDUCED SEIZURES IN MICE
| Treatments | Onset (sec) | Duration (sec) | % protection | % mortality |
|---|---|---|---|---|
| Vehicle | 74±1.72 | 198±5.40 | 0 | 100 |
| Diazepam | ---- | ----- | 100 | 0 |
| AAO 50 | 67.83±3.80 | 170.8±6.0 | 0 | 100 |
| AAO 100 | 61.00±6.86 | 166.2±18.59 | 0 | 100 |
| AAO 200 | 80.00±5.19 | 182.3±9.72 | 0 | 100 |
| AAO 400 | 245.7±25.27* | 12.67±3.18* | 50 | 50 |
| AAO 500 | 282.0±0* | 8.000±0* | 83.33 | 16.6 |
*
p<0.05 compared to vehicle control (Chi-square test). Separate groups of mice were injected with vehicle (10 ml/kg, i.p.) or diazepam (4 mg/kg, i.p.) or increasing doses of AAO (50-500 mg/kg, i.p.), and 30 min thereafter PTZ was administered individual mouse. Immediately, the mice were observed for onset and duration of general clonus and mortality. Each value represents mean±SEM of data from 5-6 mice. *p<0.05 vs. respective vehicle control (Chi-square test).