TABLE 3.
FORCED DEGRADATION BEHAVIOR OF ROFLUMILAST
| Condition | Time (h) | Temp (°) | % degradation | Area % of major degradation products |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (RRT)→ | 0.37 | 0.56 | 0.64 | 0.68 | 0.72 | 0.76 | 1.05 | |||
| Initial | 0 | 0.62 | - | - | - | - | - | - | - | 0.62 |
| 0.1 N HCl | 24 | 80 | 1.84 | - | - | 1.26 | - | - | - | 0.58 |
| Water | 24 | 80 | 0.63 | - | - | - | - | - | - | 0.63 |
| 0.1 N NaOH | 24 | 80 | 18.4 | 7.02 | 0.91 | - | 1.71 | - | 8.21 | 0.55 |
| 30% H2O2 | 24 | 80 | 2.55 | - | - | 0.67 | - | 1.1 | 0.11 | 0.67 |
| Thermal | 24 | 80 | 0.62 | - | - | - | - | - | - | 0.62 |
| UV light | 75 | 25 | 0.61 | - | - | - | - | - | - | 0.61 |