Figure 3.

Regulatory network of ESCs integrating miRs and proteins controlled by the Oct4–Sox2–Nanog trio of TFs. Genes are represented by boxes and proteins are represented by ovals or circles. Green arrows represent activation. Red lines represent repression. Proteins and genes are color-coded according to class/function: miRs are in purple, cell cycle regulators are in dark green, transcriptional regulators are in orange, DNA methytransferases are in violet, miR regulators are in brown, and signaling molecules are in light blue. Oct4, Sox2, and Nanog are depicted in green, yellow, and red, respectively.