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Increased cAMP signal intensity in oxaliplatin treated neurons. A. Immunofluorescence images of cAMP positive adult rat DRG neurons acutely treated with 8-bromo-cAMP (positive control), or oxaliplatin for 15 minutes, compared to vehicle treated neurons. Bar = 50 μm. B. Fluorescence signal intensity for cAMP immunostaining (arbitrary units), was increased in oxaliplatin treated adult rat DRG neurons compared to positive controls, and significantly higher than vehicle treated neurons.
