Table 5.
Summary of previous, concomitant and add-on therapy
| Study reference | Previous medication | Concomitant/add-on medication |
|---|---|---|
| Pregabalin | ||
| Freynhagen 2007 [27] |
Anticonvulsants (except pregabalin), Antidepressants Cannabinoids, Gabapentin, Muscle relaxants, NSAID/COX-2 inhibitor, Opioids |
Analgesics, Non-pharmacological treatment |
| Obermann 2008 [33] | Carbamazepine, Gabapentin, Oxcarbazepine | Carbamazepine, Lamotrigine |
| Sommer 2007 [34] |
Cabergoline, Gabapentin, L-DOPA, Pergolide, Pramipexole, Roprinole, Roprinole + tilidine, Tilidine |
Pramipexole + tilidine/naloxone Pramipexole + fentanyl patch |
| Ambesh 2008 [24] (A) | Current analgesic treatment regimens, Conventional pain therapies | Amitriptyline |
| Allen 2005 [26] (A) | Gabapentin | NR |
| Douglas 2008 [41] (A) [linked to Douglas 2006 [31]] | Tricyclics, Gabapentin | NR |
| Hanu-Cernat 2005 [32] (A) | Gabapentin, Pregabalin | NR |
| Stacey 2008 [29] [linked to D'Urso De Cruz 2005; D'Urso De Cruz 2005; Siffert 2005 [42-44]] | Anticonvulsants, Gabapentin, NSAIDs/Cox IIs, Opoid analgesics, Pregabalin, SSRI, SNRI, Tramadol, Tricyclics | Tricyclics, Gabapentin |
| Toth 2007 [30] (A) | Gabapentin | NR |
| Lidocaine plaster | ||
| Galer 1999 [22] | Unclear; enriched enrolment design-patients either were treated with the lidocaine plaster and requested open-label use, or were refractory to previous treatment, although type of previous treatment was unclear. | Acetaminophen, Opiates, NSAIDs, Tricyclics |
| Hines 2002 [21] | Hydrocodone/acetaminophen, NSAIDs, Sertraline, Diazepam, Rofecoxib, Oxycodone, Progesterone therapy, Gabapentin, Atenolol, Ibuprofen, Opioid analgesics, Clonidine, Citalopram, Olanzapine, Lorazepam, Cyclobenzaprine, Hormone replacement therapy, Hydrocodone, Fluoxetine, Amitriptyline, Venlafaxine, Buspirone |
Tramadol, Sustained-release diltiazem, Hormone replacement therapy, Triamterene, Amitriptyline, Sertraline, Diazepam, Rofecoxib Oxycodone controlled-release tablets, Tizanidine, Progesterone therapy, Verapamil, Clonidine, Baclofen Venlafaxine, Gabapentin |
| Devers 2000 [28] | Anticonvulsants, Eutectic mixture of local anaesthetics, Lidocaine, Mexiletine, Opoids, Prilocaine (EMLA) cream, Tricyclics | Amitriptyline, Acetamenophen, Carbamazepine, Fentanyl patch, Gabapentin, Hydromorphone, Lamotrigine, Methadone, Nortriptyline, Oxycodone, Paroxetine. |
| Robert 2005 [25](A) |
Combinations of conventional anti-neuropathic drugs: Anticonvulsants, Free radical scavengers, Ketamine, Opioids, Tricyclics. |
NR |
| Argyra 2005 [35](A) | NR | Lidocaine was tested as an add-on therapy, although other treatments were not reported. |
| Galer 2004 [20] | Cyclo-oxygenase-2 (COX-2) inhibitors, Non-selective NSAIDs, Gabapentin, Tramadol, Opioids | NR |
| Galer 2003 [36] | Topical lidocaine plaster | Anticonvulsants, Acetaminophen, Conticosteroids, Opioids, Tricyclics. |
| Duloxetine | ||
| Restivo 2008 [23] | NR | NR |