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. 2010 Sep 14;431(Pt 1):113–122. doi: 10.1042/BJ20100725

Table 2. Ki (app) of N-terminal alanine-extension mutants for MMP-1ΔC, MMP-2, MMP-3ΔC, ADAMTS-4-2 and ADAMTS-5-4.

Ki (app) (nM)
Inhibitor MMP-1ΔC MMP-2 MMP-3ΔC ADAM17 ADAMTS-4-2 ADAMTS-5-4
[−1A]N-TIMP-3 800 970 >1000 33.9±2.8 22.2±0.1 1.7±0.1
[−2A]N-TIMP-3 >1000 790 >1000 65.3±5.2 35.9±8.4 1.8±0.9
[−3A]N-TIMP-3 >1000 >1000 >1000 239 173.7 87.6
[−5A]N-TIMP-3 >1000 >1000 >1000 843 385 593
[−8A]N-TIMP-3 >1000 >1000 >1000 >1000 >1000 >1000