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Effects of cigarette extract on EFS-induced relaxation of murine cavernosal strips.
Representative tracing showing that the HPLC-purified fraction of non-burned cigarettes (5%) inhibits (A) EFS-induced relaxation, which relies on nNOS activation, but it did not interfere with (B) acetylcholine-induced relaxation, which relies on eNOS-derived NO.
Ach = acetylcholine; EFS = electrical field stimulation; PCE =purified fraction of nonburned cigarettes; PE = phenylephrine.
