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. 2010 Oct 12;285(52):40427–40437. doi: 10.1074/jbc.M110.176966

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Effects of oxotremorine-M on glutamatergic sEPSCs of lamina II neurons from M₂-KO mice. A, summary data show three types of neurons in which 3 μm oxotremorine-M had distinct effects on the frequency of sEPSCs. B, summary data from 24 neurons showing that himbacine had no effect on oxotremorine-M-induced increases in the sEPSC frequency. C, summary data from another 11 neurons showing that himbacine converted the initial inhibitory effect of oxotremorine-M on the sEPSC frequency to stimulatory. D, summary data from 6 neurons showing that oxotremorine-M similarly inhibited the frequency of sEPSCs and mEPSCs (with TTX). E, summary data from 13 neurons showing that oxotremorine-M increased the frequency of sEPSCs and mEPSCs (with TTX) in a similar manner. Data are presented as means ± S.E. *, p < 0.05 compared with the control. #, p < 0.05 compared with the initial effect of oxotremorine-M.