FIGURE 1.

CDDO-Me treatment lowers plasma TG, FFA, blood glucose, and plasma insulin levels. A–D, after 2 weeks of CDDO-Me treatment, Western diet-fed mice showed significant reduction in plasma TG level (A), plasma FFA level (B), random-fed blood glucose (C), and insulin levels (D). E–G, after 2 weeks of CDDO-Me treatment, liver and muscle tissues were extracted for total lipid (E), TG (F), and FFA (G). H, histology of liver and WAT. The liver section was stained with Oil Red O, whereas WAT was stained with hematoxylin and eosin. Shown is the number of cells presented in WAT from three different slides. Solid bar, CDDO-Me; empty bar, vehicle. The results are expressed as the means ± S.D. (n = 5 mice/group). *, p < 0.05, control versus CDDO-Me.