FIGURE 6.

Schematic diagram representing hypothesized energy levels for rM180 and the mutants. The initial state of rM180 is represented as a collection of isoenergetic states to indicate the presence of a conformation ensemble (i.e. intrinsic disorder). The partially folded state is represented as a single state to distinguish it from the disordered state. The intermediate oligomeric state is represented as several isoenergetic states of varying thickness to show the presence of aggregates of various sizes. Note that P41T denatures by reducing the energy difference between the disordered and partially folded state, whereas T21I denatures by reducing the energy difference between disordered and oligomeric state.