FIGURE 8.

CHO cells were incubated with PESDA only or with PESDA after pretreatment of the CHO cells with the oxidized ligands ox-LDL and MAA-LDL. Pretreatment with these oxidized proteins completely inhibited the binding of PESDA to SRB-1. Note that despite significant inhibition of binding to CD36, SRA, TLR-2, and TLR-4, inhibition was not complete and variable when comparing different receptors and inhibitors. *, p ≤ 0.01 compared with CHO-K1 cell binding; #, p ≤ 0.01 compared PESDA binding to each individual CHO cell expressing the scavenger receptor. Data are expressed as the mean ± S.E. of three separate experiments.