Geometric properties of Hoogsteen base pairs G:dCTP, O6-methylG:dCTP, A:dTTP, and O6-methylG:dTTP in the active site of pol ι. The C1′–C1′ distances (Å) and glycosidic bond angles (°) are shown for the G:dCTP (2ALZ) (A), O6-methylG:dCTP (B), A:dTTP (2FLL) (C), and O6-methylG:dTTP (D) base pairs.