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Overview of the electron flow of mitochondrial Trx family proteins. NADPH as the ultimate electron donor reduces thioredoxin reductase 2 (TrxR2), which among other substrates ( … ), reduces Trx2. Trx2 reduces protein disulfides, the 2-Cys Prx3, and the atypical 2-Cys Prx5. Grx2 cannot only use electrons from NADPH/GR/GSH but also from NADPH/TrxR2 for the reduction of low molecular weight disulfides (LMW(SS)), GSH-mixed disulfides (PS-SG), and the 2-Cys Prx3.
