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ITC titration of S100B to RAGE. The total heat exchanged during each injection of S100B to (A) RAGE12 and (B) MBP-RAGE12 are fit to a single-site binding model with KD and ΔH° as independent parameters, where each fitted value is shown in the inserted panels. No binding was observed for MBP-RAGE12 isoform 2 in the presence of 1 mm Ca2+ or MBP-RAGE12 in the presence of 1 mm EDTA (panel B). The values represent averages from two to three independent experiments.
