FIGURE 8.

Human AGT level is increased in plasma of double transgenic mice containing −6A haplotype of the hAGT gene as compared with −6G haplotype. A, equal amount of plasma (1 μg) from double transgenic mice containing either −6A or −6G haplotype of hAGT gene and hRen gene and from control C57 animals was analyzed by Western blot along with human plasma. The positions of molecular weight markers are shown on the left. B, histogram for the quantitation of protein level. Protein levels were normalized with albumin. AGT protein level in transgenic mice was calculated by assuming protein level in C57 mice as 1. Error bars, S.E.