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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: J Immunol. 2010 Jun 30;185(3):1777–1785. doi: 10.4049/jimmunol.1000556

Figure 6. sJAM-C stimulates angiogenesis in vivo.

Figure 6

The ability of sJAM-C to mount an in vivo angiogenic response was assessed using Matrigel and sponge granuloma assays. A-D) Matrigel was mixed with either PBS, aFGF (63 pM), or sJAM-C (100 nM) and injected into C57BL/6 mice s.c. After 7 days the plugs were removed. Representative photographs of vWF staining in Matrigel plugs treated with PBS (A), aFGF (B), and sJAM-C (C) are shown at 400x. Arrows indicate positive vWF staining. D) In a separate experiment, the amount of hemoglobin per plug was determined. E) PBS or sJAM-C (250 nM) treated sponges were implanted in C57BL/6 mice. After 7 days, the sponges were removed, homogenized, and the amount of hemoglobin per sponge was determined. Means are given with SEM. Differences were determined using the student’s t test and p values less than 0.05 were significant. Each sample was tested in duplicate. n=number of mice.