Table 2.
Associations between arylomycin C16 sensitivity and SPase genotype(s) among different wild type bacteria
| Species | Residue 29 | MIC (μg/ml) |
|---|---|---|
| Staphylococcus epidermidis | S,S | 0.25 |
| Staphylococcus haemolyticus | S,S | 2 |
| Rhodococcus opacus | V | 2 |
| Corynebacterium glutamicum | M | 2 |
| Helicobacter pylori | A | 4 |
| Yersinia pestis | P | 4 |
| Chlamydia trachomatis | L | 6 |
| Francisella tularensis | N | 4 –16, >64a |
| Streptococcus pneumoniae | N | 16 |
| Streptococcus pyogenes | A | 16 |
| Lactococcus lactis | L | 16, >128a |
| Rhodococcus equi | V,I | 16 |
| Corynebacterium efficiens | P | >64 |
| Staphylococcus aureus | P | 12–25, >128a |
| Brevibacillus brevis | P,P,P,P,V | >64 |
| Enterococcus faecalis | P,P,P,S | >64b |
| Bacillus subtilis | P,P,P,D | >128 |
| Streptococcus agalactiae | F,V | >128 |
| Escherichia coli | P | >128 |
| Pseudomonas aeruginosa | P,L | >128 |
| Klebsiella pneumoniae | P | >128 |
| Lactobacillus sakei | P,N | >128 |
| Lactobacillus gasseri | N,N | >128 |
| Lactobacillus acidophilus | N | >128 |
| Lactobacillus plantarum | M,M,V | >128 |
| Clostridium difficile | P,P,P | >16 |
| Clostridium bolteae | N,N,Q | >16 |
| Clostridium perfringens | K,K,K,I | >16 |
| Bacteroides fragilis | S,N | >16 |
| Prevotella copris | N | >16 |
a
Multiple values indicate heterogeneity within different strains of a species, as discussed in the text
b
Determined previously (Roberts et al., 2007)