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. 2011 Jan;3(1):a000778. doi: 10.1101/cshperspect.a000778

Figure 1.

Figure 1.

RNA sequences and factors involved in the regulation of alternative splicing. The upper diagram shows various patterns of alternative splicing using a 12-exon (black and colored boxes) gene that contains alternative promoters (arrows adjacent to turquoise boxes), constitutive exons (black), a retained intron (gray), a cassette and mutual exclusion exons (blue), alternative 5′ and 3′ splice sites (orange), and alternative 3′ exons with polyadenylation sites (A)n. The lower diagram highlights the conserved RNA sequence elements at the branch point (BP, U2 binding site) and the 5′ (U1 binding site) and 3′ (U2AF heterodimer binding site) splice sites of an alternatively spliced cassette exon (blue box). Also shown are the less conserved exonic and intronic splicing enhancer (ESE, ISE) and silencer (ESS, ISS) elements that are recognized by multiple factors including the SR and hnRNP proteins.