Table 3.

Predictors of recurrence-free survival in neuroendocrine tumours

Variables	Median RFS, months	P-value	Multivariate
			RR (95%CI), P-value
Tumour sizea
≥4.2 cm	97	0.005	0.06
<4.2 cm	135
Lymph node metastasesb
Present	67	0.006	0.46
Absent	128
Vascular invasion
Present	72	<0.001	8.2 (1.8–37.0), 0.007
Absent	NR
Gradec
Intermediate	65	0.02	0.61
Low	113
Surgical margin
Positive	66	0.007	0.50
Negative	128
CD3
High	99	0.52	–
Low	135
CD8
High	106	0.68	–
Low	113
CD4
High	99	0.53	–
Low	128
FoxP3
High	98	0.24	–
Low	116

^aMedian tumour size was 4.2 cm

^bOnly patients who underwent lymph node sampling were included

^cIntermediate grade defined by ≥1 mitotic figure/50 highpower fields

RFS, recurrence-free survival; RR, relative risk; 95% CI, 95% confidence interval; NR, not reported