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. 2010 Dec 10;5(12):e15165. doi: 10.1371/journal.pone.0015165

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Som et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Nodes are genes/proteins, edges are stimulations (arrows), inhibitions (T-bar arrows) and interactions (lines). The top third of the network includes upstream signaling pathways, the middle is composed of the core circuitry of pluripotency (Pou5f1 (also known as Oct4), Sox2 and Nanog) and its periphery, and the left part includes epigenetic factors and related mechanisms. At the bottom, we positioned a few small subnetworks such as the interaction of Atrx with Histone H3.3 based on [64], which are not (yet) connected to the rest of the PluriNetWork.