Table 4.
Putative immune signature in SpA
| Set 1 | Set 2 | |||||
|---|---|---|---|---|---|---|
| Gene symbol | Gene name | Fold change | Q (%) | Fold change | Q (%) | Function |
| ALOX12* | Arachidonate 12-lipoxygenase | 1.7 | 2.4 | 1.9 | 2.1 | Arachidonic acid metabolism; inflammatory response |
| BCL6* | B-cell CLL/lymphoma 6 | 1.8 | 2.4 | 1.7 | 1.5 | Pleiotropic action in immune response. Inhibits B cell apoptosis |
| CLU | Clusterin | 1.5 | 2.4 | 1.9 | 2.1 | Complement regulatory action |
| CR1 | Complement component (3b/4b) receptor 1 | 1.5 | 2.4 | 1.9 | 1.0 | Complement receptor, regulates B cell apoptosis, immune complex clearance |
| DEFA4* | Defensin, alpha 4, corticostatin | 2.1 | 2.4 | 4.2 | 1.2 | Non-specific immune response |
| FAM3B | Family with sequence similarity 3, member B | 4.9 | 2.4 | 3.6 | 1.0 | IL1-like activity |
| GRB10* | Growth factor receptor-bound protein 10 | 1.8 | 2.4 | 1.5 | 1.0 | Regulator of nuclear factor kappa B (NFKB) |
| IL1R1* | Interleukin 1 receptor type I | 1.6 | 2.4 | 2.0 | 0.4 | Binds to IL1 |
| IL1R2* | Interleukin 1 receptor, type II | 1.6 | 2.4 | 1.8 | 1.5 | Decoy target for IL1 |
| MAPK14* | Mitogen-activated protein kinase 14 | 1.5 | 2.4 | 1.6 | 1.8 | Part of the MAPK cascade |
| NCR3 | Natural cytotoxicity triggering receptor 3 | -2.5 | 4.9 | -1.7 | 1.5 | Required for NK cell-mediated induction of dendritic cell maturation |
| NLRP2/NALP2* | NLR family, pyrin domain containing 2 | -2.5 | 4.3 | -1.7 | 1.5 | Part of the inflammasome; inhibits NFkB. Causes caspase-1 activation |
| PTGS1/COX1 | Cyclooxygenase 1 | 1.9 | 2.4 | 1.8 | 2.1 | Prostaglandin synthesis. |
| SELP | Selectin P (CD62) | 1.7 | 2.4 | 1.6 | 4.1 | Extra-lymphoid T cell recruitment. Mediates Endothelial cell and leucocyte interaction |
| SLPI* | Secretory leukocyte peptidase inhibitor | 2.0 | 2.4 | 2.4 | 1.0 | Antimicrobial activity; innate host defense mechanism |
| SOD2 | Superoxide dismutase 2 | 1.7 | 2.4 | 2.8 | 1.5 | Free radical scavenging enzyme involved in defense against oxidative stress |
| SPARC | Secreted protein, acidic, cysteine-rich (osteonectin) | 3.1 | 2.4 | 2.3 | 0.8 | Involved in T cell activity and ossification |
| THBD* | Thrombomodulin | 1.5 | 2.4 | 1.7 | 3.1 | Innate immune response activity |
| THBS1 | Thrombospondin 1 | 2.0 | 2.4 | 2.0 | 2.5 | Glycoprotein |
| TREM1 | Triggering receptor expressed on myeloid cells-like 1 | 1.9 | 2.4 | 2.1 | 2.5 | Amplifies response of NLRP2 |
Significantly differentially expressed genes with a recognized immune or inflammation-related function present in Set 1 and Set 2. Functional annotations were obtained from Online Mendelian Inheritance in Man database [32]. *Secondary analysis indicates that expression level changes are more apparent in males.