Table 2.
Cytokines in salivary gland extract and plasma
| Salivary gland extract (pg/ml per 20 mg wet SG) |
Plasma (pg/ml) | |||||
|---|---|---|---|---|---|---|
| LacZ | TNFR1:IgG | P value | LacZ | TNFR1:IgG | P value | |
| mTNF-α | 73.0 (53.0) | 24.6 (2.5) | 0.9273 | 21.2 (5.3) | 45.5 (15.3) | 0.3152 |
| MCP-1 | 325.0 (222.7) | 254.6 (70.6) | 1.0000 | 182.0 (49.0) | 95.1 (10.8) | 0.0727 |
| mIL-4 | 23.0 (12.2) | 3.8 (1.0) | 0.0727 | 1.2 (0.05) | 16.1 (2.3) | *0.0061 |
| mIL-5 | 94.5 (41.4) | 7.3 (1.9) | *0.0061 | 2.3 (0.04) | 30.7 (8.3) | 0.0727 |
| mIL-6 | 109.9 (61.4) | 42.4 (15.2) | 0.3152 | 20.7 (8.8) | 37.0 (5.7) | 0.1636 |
| mIFN-γ | 657.9 (305.5) | 614.9 (216.1) | 0.5273 | 192.9 (28.5) | 511.7 (75.0) | *0.0061 |
| mIL-10 | 37.6 (14.8) | 7.7 (2.0) | 0.0727 | 3.0 (0.4) | 27.5 (3.3) | *0.0061 |
| mTGF-β1 | 4342 (1742) | 3.0E6 (7.8E5) | *0.0061 | 7.8E5 (8.1E4) | 1840 (187.7) | *0.0061 |
| mIL-12p70 | 130.2 (54.3) | 6.3 (2.3) | *0.0061 | 18.3 (11.0) | 65.8 (7.4) | *0.0242 |
| mIL-17 | 53.2 (24.3) | 5.4 (1.6) | *0.0242 | 6.4 (3.1) | 12.1 (1.8) | 0.1636 |
| hTNFR1 | 0.0 (0.0) | 114.4 (43.5) | ND | |||
Protein expression of immunomodulatory molecules after administration of LacZ and TNFR1:IgG in salivary gland extract and plasma. Data shown are mean values +/- SEM. Significant differences are indicated (*) and were determined by non-parametric Wilcoxon's ranksum test. LacZ (N = 4) and TNFR1:IgG (N = 7). ND = not determined.