Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Dec 10;11(6):R185. doi: 10.1186/ar2877

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright ©2009 Le Goff et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Representative TRAP staining profiles. The (a) control, (b) zoledronic acid (ZA), (c) methotrexate (MTX), and (d) ZA + MTX groups are shown (×40). (e) Erosion score. Bone erosion was strongly inhibited in the ZA group. MTX also significantly reduced bone erosion, although to a lesser extent than ZA. (f) Number of osteoclasts (multinucleated tartrate resistant acid phosphatase (TRAP) positive cells) at the bone/synovium interface in the eroded joint of the tibiotarsal and intertarsal joints. ZA, used alone or in combination with MTX, strongly decreased the number of TRAP-positive cells. MTX also decreased the number of TRAP+ cells in the eroded joint. *P < 0.05 versus computed tomography (CT) group; **P < 0.005 versus CT group; +P < 0.05 versus MTX group.