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. 2009 Nov 9;11(6):R167. doi: 10.1186/ar2854

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Copyright ©2009 Iwanami et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Human glucose-6-phosphate isomerase-specific Th17 cells use TCRVβ8.1 8.2. Many glucose-6-phosphate isomerase hGPI_325--339-specific Th17 cells use TCRVβ8.1 8.2. Mice were immunized with 10 μg hGPI_325--339, and draining lymph node cells on day 6 were stimulated with 20 μM hGPI_325--339in vitro. (a) Ratios of TCRVβ repertoire to CD4⁺T cells. The TCRVβ repertoire of CD4⁺T cells was analyzed by flow cytometry: before stimulation with hGPI_325--339in vitro for 72 hours, and after stimulation. (b) GoldiStop was added in the last 4 hours of the 24-hour culture. Flow cytometry analysis for IL-17 was gated in CD4^highcells. Representative data of two independent experiments.