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. Author manuscript; available in PMC: 2011 Nov 12.
Published in final edited form as: Cell. 2010 Nov 12;143(4):527–539. doi: 10.1016/j.cell.2010.10.016

Figure 2.

Figure 2

Neural differentiation of iPSCs. (A), Schematic view of the neural differentiation protocol. (B), Representative images depicting morphological changes during neuronal differentiation. Bar = 100 μm. (C), NPCs are positive for neural precursor markers: Sox1, Sox2, Musashi1 and Nestin. Bar = 50 μm. (D), Representative images of cells after neuronal differentiation. iPSC-derived neurons express mature neuronal markers: GABA, Map2 and Synapsin. Bar = 20 μm. Similar numbers of Map2-positive and Syn::DsRed-positive (E) as well as GABA-positive (F) neurons from WT and RTT cultures. Data shown as mean ± s.e.m. See also Figure S2.