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CDK5miR reduces CDK5 expression in the brain of triple-transgenic Alzheimer mice. 3×Tg-AD mice (18–23 months of age) were killed 3 weeks after injection with AAV. Silencing of CDK5 expression by CDK5miR in the dentate gyrus, CA1, CA2, and CA3 regions of 3×Tg-AD mice. GFP represent the transduced areas in the hippocampus. Magnification, 15×. Scale bar, 100 μm. CDK5 immunofluorescence: magnification, 40×. Scale bar, 50 μm. n = 6.
