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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Nat Neurosci. 2010 Aug 8;13(9):1082–1089. doi: 10.1038/nn.2611

Figure 3.

Figure 3

Expression of a BAC construct containing Arc and its genomic regulatory regions rescues early- and late-phase LTD in Arc−/− neurons. (a) LTD induced by glutamate and depolarization pairing. Scale bars represent 2 s and 40 pA. Arc−/− and Arc-BAC (n = 8), Arc+/+ and Arc-BAC (n = 7), Arc−/− and SRE 6.9 mutant BAC (n = 8), Arc−/− and SRE 1.1 mutant BAC (n = 7). Statistical comparisons at t = 120 min for the paired pathway: Arc−/− and Arc-BAC versus Arc−/− and SRE 6.9 mutant BAC, P < 0.005; Arc−/− and SRE 6.9 mutant BAC versus Arc−/− and SRE 1.1 mutant BAC, P < 0.01. (b) Chemical LTD induced by PDA (n = 10 cells per group). Statistical comparisons at t = 90 min: Arc−/− and Arc-BAC versus Arc−/− and SRE 6.9 mutant BAC, P < 0.02; Arc−/− and SRE 6.9 mutant BAC versus Arc−/− and SRE 1.1 mutant BAC, P < 0.02. Error bars represent the s.e.m. (c) Schematic diagram of the Arc promoter showing two SREs, where SRF can bind, and the ATG start codon.