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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: J Neurochem. 2010 Nov 19;115(6):1681–1689. doi: 10.1111/j.1471-4159.2010.07077.x

Figure 3.

Figure 3

Blocking Glutamate uptake elevates extracellular D-serine by acting through AMPA receptors. (A) Raw trace showing glutamate (Glu) increase following a 50 minute incubation in 10 μM TFB-TBOA. (B) TFB-TBOA significantly elevated Glu in all conditions tested. There was no difference in Glu between experiments where TFB-TBOA was added. (C) TFB-TBOA elevated D-serine in the presence of cyclothiazide which was blocked by the application of 50 μM GYKI. A, B, C DAO- retinas (*, statistically different from control, p<0.05, n=6-7).