Fig. 2.

Reduction of PPARγ expression in Ramos B lymphoma cells results in enhanced proliferation and reduced sensitivity to PPARγ ligand induced cell death. a LV-control and LV-PPARγ-siRNA transduced Ramos B lymphoma cells were untreated or treated with 1:1,000 Pansorbin (fixed S. aureus), human CD40L, 10 μg/ml anti-IgM, a combination of CD40L + anti-IgM, and CD40L + Pansorbin for 24 h. Proliferation was measured by [³H] thymidine incorporation. b LV-Control and LV-PPARγ-siRNA infected Ramos cells were exposed to increasing concentrations of the PPARγ ligand CDDO. Viability was measured by MTT assay. PPARγ-knockdown Ramos cells have increased survival in comparison to control cells when exposed to the PPARγ agonist CDDO. (*P < 0.05), ns not significant