Resource	Unit cost (2008 €)	Source	Units/cycle	Cycles
TRA treatment
Yondelis 2 × 1 mg + 1 × 0.25 mg; dexamethasone, pharmacy Or hospital price for above (optional base case scenario)	5236.47 4528.68	[1]	1	5
Administration; laboratory tests; travellinga	751.14	[2]b	1	5
ETO EST (120 mg/m2)
Etoposid 20 mg/ml, 3 × 5 ml	60.00	[1]	3	6
Administration	679.42	[2]b	3	6
Laboratory tests and travellinga	66.90	[2]b	1	6
DAC EST (250 mg/m2)
Dadatic 2 × 200 mg + 1 × 100 mg	53.93	[1]	5	6
Administration	679.42	[2]b	5	6
Laboratory tests and travellinga	108.62	[2]b	1	6
IADIC EST
Adriamycin 2 mg/ml, 2 × 25 ml; Haloxan 1 g/m2, 2 g; Uromitexan 100 mg/ml, 40 mg/kg, 2 × 10 ml + 1 × 4 ml; Dadatic 2 × 200 mg + 1 × 100 mg	231.75	[1]	1	6
Administration	679.42	[2]b	5	6
Laboratory tests and travellinga	108.62	[2]b	1	6
IE EST
Haloxan 1 g/m2, 2 g; Uromitexan 100 mg/ml, 40 mg/kg, 2 × 10 ml + 1 × 4 ml	42.58	[1]	5	6
Etoposid 100 mg/m2, 20 mg/ml, 2 × 5 ml	40.00	[1]	3	6
Luminaletten 100 mg, 7 × 15 mg	0.85	[1]	6	6
Neulasta 6 mg	1298.08	[1]	1	6
Administration	679.42	[2]b	5	6
Laboratory tests and travellinga	66.90	[2]b	1	6
IMVP-a6 EST
Haloxan 1 g/m2, 2g; Uromitexan 100 mg/ml, 40 mg/kg, 2 × 10 ml + 1 × 4 ml	42.58	[1]	5	6
Etoposid 100 mg/m2, 20 mg/ml, 2 × 5 ml	40.00	[1]	3	6
Methotrexate 30 m2, 25 mg/ml, 3 × 1 ml	8.73	[1]	2	6
Administration	679.42	[2]b	7	6
Laboratory tests and travelling	33.87	[2]b	1	6
Travelling to administration	33.03	[2]b	2	6
SAE related to TRA
Treatment and travelling	1472.90	[2]b	0.054	1
after A/I failure
Ongoing treatment	607.32	[3]c	1

^aTravelling to administration (€33.03) and to laboratory (€6.49).

^bIndexed from 2006 to 2008 price level with the factor of 1.0951 obtained from the Official Statistics Finland.

^cIndexed from 2005 to 2008 price level (€3042.44 during 4.98 months; €607.32 per cycle).

A/I = anthracycline and/or ifosfamide; DAC, dacarbazine; EST, end-stage treatment; ETO = etoposid; IADIC, doxorubicin, ifosfamide, mesna and DAC; IE, ifosfamide, mesna, ETO, phenobarbital and growth hormone; IMVP-6a, ifosfamide, mesna, ETO and methotrexate; SAE = serious adverse event; TRA, trabectedin.