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SR1078 dose-dependently activates RORα and RORγ directed transcription. HEK293 cells were cotransfected with full length RORα (A and C) or RORγ (B and D) along with the FGF21 (A and B) and G6Pase (C and D) reporter as described in Figure 2. In all cases, SR1078 induced expression of the target gene reporter dose-dependently with significant activation occurring in the range of 2–5 μM. *, indicates p<0.05.
