Table 1. Demographic, clinical and radiographic characteristics, stratified by study.
| ISGS/SWISS | MGH | |||
|---|---|---|---|---|
| Cases | Controls | Cases | Controls | |
| No. | 602 | 444 | 575 | 661 |
| Age (yrs.), mean (SD) | 65.7 (13.5) | 67.9 (14.8) | 65.6 (15.8) | 68.9 (9.3) |
| Sex (% male) | 53 | 59 | 57 | 51 |
| HTN (%) | 67 | 37 | 52 | 33 |
| DM II (%) | 23 | 11 | 26 | 18 |
| Smoking (% current) | 20 | 8.6 | 25 | 20 |
| No. WMH | 189 | -- | 603* | -- |
| WMH volume (cc) | 5.3 (2.6–11.1) | -- | 10.2 (4.8–22.9) | -- |
| TOAST Stroke Subtypes | ||||
| Cardioembolic | 150( 0.25) | -- | 230 (0.40) | -- |
| Large Artery | 114 (0.19) | -- | 104 (0.18) | -- |
| Small Vessel | 103 (0.17) | -- | 63 (0.11) | -- |
| Other Determined Etiology | 24 (0.04) | -- | 132 (0.23) | -- |
| Undetermined Etiology | 211 (0.35) | -- | 46 (0.08) | -- |
| GCNKSS | JUSS | |||
| Cases | Controls | Cases | Controls | |
| No. | 459 | 290 | 648 | 333 |
| Age (yrs.), mean (SD) | 70.4 (12.9) | 62.0 (14.9) | 64.2 (17.1) | 64.6 (15.0) |
| Sex (% male) | 52 | 47 | 51 | 49 |
| HTN (%) | 70 | 49 | 48 | 42 |
| DM II (%) | 36 | 16 | 17 | 22 |
| Smoking (% current) | 26 | 20 | 27 | 18 |
| TOAST Stroke Subtypes | ||||
| Cardioembolic | 105 (0.23) | -- | -- | -- |
| Large Artery | 69 (0.15) | -- | -- | -- |
| Small Vessel | 92 (0.20) | -- | -- | -- |
| Other Determined Etiology | 9 (0.02) | -- | -- | -- |
| Undetermined Etiology | 184 (0.40) | -- | -- | -- |
*
Individuals analyzed for white matter hyperintensity volume from MGH are greater than the total analyzed ischemic stroke cases because quality control procedures were implemented independently for the two cohorts.
All included individuals are of self-reported European or European-American ancestry. DM II = Type II Diabetes Mellitus, GCNKSS = Greater Cincinnati Northern Kentucky Stroke Study, HTN = Hypertension, ISGS/SWISS = Ischemic Stroke Genetic Study/Siblings with Ischemic Stroke Study, JUSS = Jagiellonian University Stroke Study, MGH = Massachusetts General Hospital Ischemic Stroke Genome-wide Association Study, SD = Standard Deviation, WMH = White Matter Hyperintensity