Table 2. Meta-analysis of leading SNPs in association with ischemic stroke.
Results for the SNPs with the lowest unadjusted p-values in meta-analysis of all four cohorts, after exclusion of SNPs genotyped adequately in fewer than 3 cohorts.
| SNP | OR | p | I2 | MAF | |||
|---|---|---|---|---|---|---|---|
| ISGS/SWISS | MGH | GCNKSS | JUSS | ||||
| mt930 | 0.81 | 0.03 | 0.00 | 0.059 | 0.045 | 0.046 | 0.043 |
| mt5147 | 0.80 | 0.03 | 0.00 | 0.057 | 0.045 | 0.046 | 0.043 |
| mt10915 | 1.35 | 0.08 | 0.00 | 0.012 | 0.013 | 0.017 | 0.013 |
| mt4580 | 0.83 | 0.11 | 0.34 | 0.032 | 0.032 | 0.039 | 0.028 |
| mt5426 | 0.80 | 0.13 | 0.00 | 0.015 | 0.018 | 0.017 | N/A |
| mt6221 | 0.83 | 0.15 | 0.00 | 0.015 | 0.020 | 0.012 | 0.019 |
| mt12633 | 1.33 | 0.15 | 0.38 | 0.030 | 0.020 | 0.019 | N/A |
| mt13879 | 0.78 | 0.15 | 0.00 | 0.009 | 0.013 | 0.010 | 0.010 |
| mt14233 | 0.86 | 0.18 | 0.00 | 0.095 | 0.072 | 0.086 | 0.075 |
| mt11812 | 0.86 | 0.18 | 0.00 | 0.095 | 0.072 | 0.086 | 0.077 |
GCNKSS = Greater Cincinnati Northern Kentucky Stroke Study, I2 = % of effect size attributable to meta-analysis heterogeneity, ISGS/SWISS = Ischemic Stroke Genetic Study/Siblings with Ischemic Stroke Study, JUSS = Jagiellonian University Stroke Study, MAF = Minor Allele Frequency, MGH = Massachusetts General Hospital Ischemic Stroke Genome-wide Association Study, N/A = SNP not available in this cohort, OR = Odds Ratio, SNP = Single Nucleotide Polymorphism