Table 4. Mitochondrial genetic score-based analysis by cohort and in meta-analysis.
| Study | Cases | Controls | OR | 95% CI | P* |
|---|---|---|---|---|---|
| MGH | 575 | 661 | 1.13 | 1.02 – 1.26 | 0.021 |
| ISGS/SWISS | 602 | 444 | 1.18 | 1.05 – 1.32 | 0.006 |
| GCNKSS | 459 | 290 | 1.10 | 0.95 – 1.28 | 0.189 |
| JUSS | 648 | 333 | 1.09 | 0.97 – 1.23 | 0.059 |
| Meta-Analysis | Cases | Controls | OR | 95% CI | p |
| Fixed Effects | 2284 | 1728 | 1.13 | 1.06 – 1.20 | < 0.0001 |
| Random Effects | 2284 | 1728 | 1.13 | 1.06 – 1.20 | < 0.0001 |
*
Unadjusted p-values shown.
CI = Confidence Interval, GCNKSS = Greater Cincinnati Northern Kentucky Stroke Study, ISGS/SWISS = Ischemic Stroke Genetic Study/Siblings with Ischemic Stroke Study, JUSS = Jagiellonian University Stroke Study, MGH = Massachusetts General Hospital Ischemic Stroke Genome-wide Association Study, OR = Odds Ratio. The OR shown for each study and in meta-analysis represent the risk of ischemic stroke associated with each quintile increase in the mitochondrial genetic score.