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. Author manuscript; available in PMC: 2011 Dec 17.
Published in final edited form as: ACS Chem Biol. 2010 Oct 7;5(12):1115–1124. doi: 10.1021/cb100245u

Figure 2.

Figure 2

Triazole-containing RNAs were generated from N2-propargyl 2-aminopurine-containing RNA via CuAAC reaction. A, generation of N-ethylpiperidine triazole RNA (PipNEt). B, Thermal denaturation analysis of the PipNEt triazole modification in a 12 mer duplex indicates that the stability and specificity of the modification is comparable to that of adenosine.