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A, Westen blot for PKR showing reduction in binding affinity as a result of propargyl modification (lanes 3 and 4) and ManNAc triazole modification (lanes 5 and 6) in the passenger strand, relative to unmodified siRNA (lane 2). B, Plot showing PKR binding (relative to unmodified siRNA) for the modified siRNAs that displayed the highest RNAi activity.
