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. 2010 Oct 20;119(1):189–208. doi: 10.1093/toxsci/kfq314

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© The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

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FIG. 5 — CYP1A1 and CYP1A2 mRNA levels, quantified by qRT-PCR. (Top row) GD11.5. CYP1A1 induction was significantly higher in Ahr^b1-containing maternal liver compared with Ahr^d-containing mothers. CYP1A2 mRNA levels were 40-fold higher in Ahr^b1_Cyp1a2(+/+) maternal liver compared with Ahr^d_Cyp1a2(+/+) mothers. In this and in subsequent panels, all values represent mean values of fold induction over corn oil–treated B6 controls ± SEM. N = 3–5 per group. Interindividual and group statistics are available upon request. (Second row) GD18.5. CYP1A1 induction was significantly higher in Ahr^b1-containing maternal and pup liver compared with Ahr^d-containing mothers and pups. CYP1A2 mRNA levels were ∼10-fold higher in Ahr^b1_Cyp1a2(+/+) maternal liver compared with Ahr^d_Cyp1a2(+/+) mothers and ∼100-fold higher in Ahr^b1_Cyp1a2(+/+) pup liver compared with Ahr^d_Cyp1a2(+/+) pups. (Third row) PND6. CYP1A1 induction was ∼1000-fold higher in Ahr^b1-containing maternal and pup liver compared with Ahr^d-containing mothers and pups. CYP1A2 mRNA levels were approximately eightfold higher in Ahr^b1_Cyp1a2(+/+) maternal liver compared with Ahr^d_Cyp1a2(+/+) mothers and > 10-fold higher in Ahr^b1_Cyp1a2(+/+) pup liver compared with Ahr^d_Cyp1a2(+/+) pups. (Fourth row) PND13. CYP1A1 induction was significantly higher in Ahr^b1-containing maternal and pup liver compared with Ahr^d-containing mothers and pups. CYP1A2 mRNA levels were approximately sixfold higher in Ahr^b1_Cyp1a2(+/+) maternal liver compared with Ahr^d_Cyp1a2(+/+) mothers and > 15-fold higher in Ahr^b1_Cyp1a2(+/+) pup liver compared with Ahr^d_Cyp1a2(+/+) pups. (Bottom row) PND28. CYP1A1 induction was significantly higher in Ahr^b1_Cyp1a2(−/−) maternal liver compared with mothers from the other three genotypes. CYP1A1 induction was highest in Ahr^b1-containing pup liver compared with Ahr^b1-containing maternal liver and Ahr^d-containing pup liver. In pup brain, CYP1A1 was significantly induced in Ahr^b1_Cyp1a2(−/−) pups compared with pups from the other three genotypes. CYP1A2 mRNA was significantly higher in both Ahr^b1_Cyp1a2(+/+) and Ahr^d_Cyp1a2(+/+) pup liver. In this figure and the next, “significantly” denotes p values anywhere between < 0.05 and < 0.0001.