TABLE 10.
Noncoplanar PCB Congener Analysis on PND6
| Genotype | Tissue | PCB 105 | PCB 118 | PCB 138 | PCB 153 | PCB 180 |
| Ahrb1Cyp1a2(+/+) | Maternal brain | 17.7 ± 1.4 | 17.2 ± 1.6 | 18.6 ± 1.4 | 16.9 ± 1.3 | 32.1 ± 1.6 |
| AhrdCyp1a2(+/+) | 26.2 ± 2.9 | 24.5 ± 3.2 | 25.6 ± 3.6 | 21.9 ± 3.6 | 40.0 ± 4.2 | |
| Ahrb1Cyp1a2(−/−) | 24.2 ± 2.2 | 22.7 ± 2.0 | 22.5 ± 2.9 | 20.4 ± 3.2 | 36.9 ± 3.2 | |
| AhrdCyp1a2(−/−) | 17.2 ± 2.2 | 15.6 ± 2.2 | 17.8 ± 3.3 | 17.2 ± 2.9 | 30.5 ± 5.2 | |
| Ahrb1Cyp1a2(+/+) | Maternal liver | 79.2 ± 8.8 | 60.8 ± 7.4 | 70.6 ± 5.4 | 41.9 ± 4.4 | 81.8 ± 4.0 |
| AhrdCyp1a2(+/+) | 95.6 ± 14 | 70.6 ± 13 | 76.6 ± 13 | 51.0 ± 10 | 86.6 ± 15 | |
| Ahrb1Cyp1a2(−/−) | 82.7 ± 14 | 59.5 ± 13 | 72.2 ± 14 | 45.4 ± 14 | 85.3 ± 20 | |
| AhrdCyp1a2(−/−) | 71.6 ± 13 | 50.3 ± 10 | 62.1 ± 10 | 39.0 ± 8.3 | 76.5 ± 15 | |
| Ahrb1Cyp1a2(+/+) | Maternal inguinal fat pad | 538 ± 29 | 507 ± 18 | 536 ± 16 | 450 ± 13 | 524 ± 22 |
| AhrdCyp1a2(+/+) | 586 ± 54 | 545 ± 59 | 488 ± 41 | 414 ± 44 | 445 ± 33 | |
| Ahrb1Cyp1a2(−/−) | 642 ± 16 | 585 ± 13 | 569 ± 16 | 460 ± 11 | 521 ± 25 | |
| AhrdCyp1a2(−/−) | 464 ± 52 | 463 ± 12 | 441 ± 42 | 376 ± 29 | 428 ± 29 | |
| Ahrb1Cyp1a2(+/+) | Maternal mammary tissue | 267 ± 66 | 246 ± 61 | 240 ± 52 | 189 ± 41 | 268 ± 33 |
| AhrdCyp1a2(+/+) | 377 ± 48 | 346 ± 44 | 338 ± 42 | 249 ± 34 | 320 ± 28 | |
| Ahrb1Cyp1a2(−/−) | 285 ± 49 | 259 ± 46 | 249 ± 45 | 188 ± 36 | 252 ± 28 | |
| AhrdCyp1a2(−/−) | 256 ± 27 | 215 ± 16 | 223 ± 15 | 182 ± 28 | 250 ± 31 | |
| Ahrb1Cyp1a2(+/+) | Pup brain | 29.6 ± 4.5 | 27.6 ± 3.4 | 27.1 ± 4.8 | 22.6 ± 3.9 | 31.6 ± 7.4 |
| AhrdCyp1a2(+/+) | 32.4 ± 4.8 | 32.2 ± 5.2 | 28.9 ± 5.2 | 24.0 ± 4.4 | 30.0 ± 4.8 | |
| Ahrb1Cyp1a2(−/−) | 25.9 ± 3.5 | 24.4 ± 3.1 | 19.1 ± 2.7 | 17.5 ± 2.1 | 22.0 ± 3.5 | |
| AhrdCyp1a2(−/−) | 19.5 ± 2.1 | 18.0 ± 0.8 | 17.3 ± 1.6 | 14.9 ± 1.3 | 21.1 ± 3.6 | |
| Ahrb1Cyp1a2(+/+) | Pup liver | 235 ± 52 | 209 ± 47 | 210 ± 42 | 164 ± 34 | 254.8 ± 45 |
| AhrdCyp1a2(+/+) | 156 ± 28 | 123 ± 26 | 117 ± 21 | 101 ± 23 | 145 ± 26 | |
| Ahrb1Cyp1a2(−/−) | 271 ± 25 | 235 ± 23 | 220 ± 19 | 178 ± 16 | 246.0 ± 18 | |
| AhrdCyp1a2(−/−) | 269 ± 40 | 233 ± 37 | 243 ± 38 | 198 ± 32 | 297 ± 40 | |
| Ahrb1Cyp1a2(+/+) | Pup total adipose tissue | 508 ± 25 | 454 ± 23 | 417 ± 19 | 317 ± 11 | 343 ± 12 |
| AhrdCyp1a2(+/+) | 434 ± 81 | 378 ± 74 | 351 ± 73 | 269 ± 52 | 279 ± 67 | |
| Ahrb1Cyp1a2(−/−) | 626 ± 42 | 547 ± 39 | 487 ± 38 | 371 ± 30 | 384 ± 38 | |
| AhrdCyp1a2(−/−) | 543 ± 43 | 475 ± 40 | 406 ± 35 | 326 ± 29 | 318 ± 36 | |
| Ahrb1Cyp1a2(+/+) | Pup stomach | 329 ± 11 | 291 ± 2.0 | 272 ± 8.0 | 206 ± 10 | 253 ± 15 |
| AhrdCyp1a2(+/+) | 353 ± 51 | 307 ± 49 | 270 ± 46 | 205 ± 38 | 242 ± 36 | |
| Ahrb1Cyp1a2(−/−) | 348 ± 23 | 305 ± 22 | 271 ± 20 | 211 ± 15 | 253 ± 24 | |
| AhrdCyp1a2(−/−) | 347 ± 47 | 300 ± 41 | 287 ± 41 | 224 ± 34 | 273 ± 42 |
Note. These tissues were collected 24 h after the second gavage on PND5.