TABLE 12.
Noncoplanar PCB Congener Analysis on PND13
| Genotype | Tissue | PCB 105 | PCB 118 | PCB 138 | PCB 153 | PCB 180 |
| Ahrb1Cyp1a2(+/+) | Maternal brain | 8.96 ± 4.2 | 8.07 ± 3.9 | 10.0 ± 4.1 | 7.69 ± 2.9 | 11.6 ± 3.4 |
| AhrdCyp1a2(+/+) | 5.22 ± 0.70 | 4.36 ± 0.93 | 5.00 ± 1.2 | 4.31 ± 1.1 | 6.55 ± 1.9 | |
| Ahrb1Cyp1a2(−/−) | 9.45 ± 3.9 | 8.48 ± 3.9 | 10.1 ± 4.3 | 8.33 ± 3.2 | 13.9 ± 4.5 | |
| AhrdCyp1a2(−/−) | 3.65 ± 1.3 | 3.26 ± 1.4 | 3.97 ± 1.3 | 3.63 ± 1.1 | 6.59 ± 2.2 | |
| Ahrb1Cyp1a2(+/+) | Maternal liver | 16.0 ± 4.8 | 10.8 ± 3.4 | 37.6 ± 7.9 | 13.3 ± 3.8 | 52.0 ± 7.8 |
| AhrdCyp1a2(+/+) | 17.8 ± 3.6 | 11.4 ± 3.0 | 36.4 ± 7.5 | 13.4 ± 3.6 | 47.0 ± 10 | |
| Ahrb1Cyp1a2(−/−) | 41.3 ± 19 | 25.9 ± 12 | 58.3 ± 12 | 24.3 ± 8.6 | 70.7 ± 2.5 | |
| AhrdCyp1a2(−/−) | 8.65 ± 0.75 | 4.50 ± 0.54 | 26.4 ± 1.4 | 6.31 ± 0.69 | 39.1 ± 4.4 | |
| Ahrb1Cyp1a2(+/+) | Maternal inguinal fat pad | 188 ± 79 | 213 ± 79 | 333 ± 96 | 303 ± 82 | 448 ± 88 |
| AhrdCyp1a2(+/+) | 249 ± 38 | 270 ± 46 | 400 ± 66 | 356 ± 58 | 469 ± 21 | |
| Ahrb1Cyp1a2(−/−) | 393 ± 170 | 353 ± 120 | 507 ± 95 | 440 ± 49 | 625 ± 26 | |
| AhrdCyp1a2(−/−) | 235 ± 54 | 278 ± 53 | 424 ± 59 | 382 ± 45 | 525 ± 47 | |
| Ahrb1Cyp1a2(+/+) | Maternal mammary tissue | 21.1 ± 9.3 | 24.3 ± 10 | 38.7 ± 15 | 32.0 ± 12 | 66.7 ± 24 |
| AhrdCyp1a2(+/+) | 27.1 ± 3.6 | 30.5 ± 5.0 | 44.1 ± 7.5 | 36.1 ± 5.9 | 74.7 ± 8.2 | |
| Ahrb1Cyp1a2(−/−) | 113 ± 36 | 113 ± 33 | 155 ± 36 | 132 ± 24 | 246 ± 27 | |
| AhrdCyp1a2(−/−) | 11.3 ± 2.3 | 14.2 ± 2.9 | 24.8 ± 4.6 | 21.3 ± 3.8 | 53.6 ± 11.1 | |
| Ahrb1Cyp1a2(+/+) | Pup brain | 23.2 ± 3.8 | 21.1 ± 2.9 | 23.5 ± 4.0 | 18.2 ± 3.3 | 23.9 ± 4.3 |
| AhrdCyp1a2(+/+) | 27.8 ± 6.1 | 23.9 ± 5.8 | 21.0 ± 5.3 | 16.3 ± 3.9 | 19.0 ± 4.8 | |
| Ahrb1Cyp1a2(−/−) | 47.9 ± 4.5 | 41.4 ± 5.6 | 37.8 ± 3.6 | 29.0 ± 2.9 | 37.0 ± 3.7 | |
| AhrdCyp1a2(−/−) | 23.7 ± 8.5 | 20.9 ± 6.9 | 18.1 ± 6.2 | 14.6 ± 5.0 | 16.6 ± 5.3 | |
| Ahrb1Cyp1a2(+/+) | Pup liver | 98.6 ± 8.6 | 79.6 ± 6.3 | 77.6 ± 6.6 | 48.2 ± 4.8 | 68.2 ± 7.1 |
| AhrdCyp1a2(+/+) | 64.7 ± 1.3 | 51.3 ± 7.4 | 52.8 ± 11 | 36.9 ± 11 | 49.1 ± 13 | |
| Ahrb1Cyp1a2(−/−) | 231 ± 33 | 181 ± 28 | 175 ± 24 | 123 ± 22 | 161 ± 21 | |
| AhrdCyp1a2(−/−) | 77.8 ± 25 | 58.1 ± 19 | 58.1 ± 19 | 39.0 ± 14 | 50.7 ± 18 | |
| Ahrb1Cyp1a2(+/+) | Pup total adipose tissue | 624 ± 70 | 558 ± 57 | 562 ± 56 | 442 ± 42 | 482 ± 42 |
| AhrdCyp1a2(+/+) | 594 ± 120 | 518 ± 88 | 501 ± 72 | 412 ± 37 | 429 ± 48 | |
| Ahrb1Cyp1a2(−/−) | 740 ± 26 | 691 ± 38 | 651 ± 26 | 497 ± 12 | 551 ± 12 | |
| AhrdCyp1a2(−/−) | 636 ± 34 | 566 ± 27 | 535 ± 26 | 428 ± 25 | 459 ± 30 | |
| Ahrb1Cyp1a2(+/+) | Pup plasma | 17.9 ± 3.8 | 16.7 ± 3.3 | 17.8 ± 3.3 | 15.3 ± 3.4 | 16.9 ± 2.9 |
| AhrdCyp1a2(+/+) | 15.6 ± 1.0 | 13.7 ± 0.84 | 11.5 ± 0.8 | 9.7 ± 0.7 | 9.6 ± 1.0 | |
| Ahrb1Cyp1a2(−/−) | 35.7 ± 2.1 | 34.1 ± 1.3 | 28.8 ± 1.2 | 24.3 ± 0.8 | 28.2 ± 0.4 | |
| AhrdCyp1a2(−/−) | 11.8 ± 0.9 | 11.2 ± 0.9 | 9.6 ± 0.8 | 8.8 ± 0.4 | 7.9 ± 0.4 |
Note. These tissues were collected 8 days after the second gavage to the mother on PND5.